Endocrine Abstracts

Adrenal masses are among the most prevalent human tumors and are frequently detected unexpectedly by imaging studies performed for reasons unrelated to suspect of adrenal diseases.Subclinical hypercortisolism (SH) is the most frequent endocrine dysfunction detected in patients with adrenal incidentalomas (AI), accounting from five to 20% of all cases depending on inclusion criteria. one mg overnight dexamethasone suppression test (one mg DST) should be t...

Introduction: The antitumor activity of a novel cyclic amide, CLM94, with anti-VEGFR-2 and antiangiogenic activity, in primary anaplastic thyroid cancer (ATC) cells in vitro and in vivo, has been studied.Design and Methods: CLM94 was tested: i) in two human cell lines (HMVEC-d, dermal microvascular endothelial cells; 8305C, undifferentiated thyroid cancer) at 0.001–100 mcM; ii) in ATC cells at the concentrations of 10, 30, 50 mcM; iii)...